Change the denominator (bottom) of the fractions so that they are similar. To do this, multiply both fractions by the number found in the other denominator. For example, if you want to subtract 2/3 from 1/4, multiple 2/3 by 4 (to get 8/12) and 1/4 by 3 (to get 3/12).
Subtract the numerators. In our previous example, you would subtract 8/12 from 3/12 and get -5/12 as your answer.
Simplify the fraction, if necessary.
Simplify the fraction. For example, if your are multiplying 2/3 by 4/8, first reduce 4/8 to 1/2.
Multiply the numerators together to find the product's numerator: 2 times 1 is 1.
Multiply the denominators together to find the product's denominator: 3 times 2 is 6.
Simplify the new fraction, if possible. In this example, 1/6 is as simple as it can be.