Expand the innermost set of parentheses, using the usual order of operations. For example, suppose the equation is
4*(3*(8-5)^2 +2). The inner set of parentheses is (8-5) so evaluate that and get
4*(3*3^2 + 2).
Expand the next set of parentheses, again following the usual order of operations. The next set of parentheses is (3*3^2+2). First take powers, getting 4*(3*9+2) then multiply getting 4*(27+2). Then add, getting 4*29.
Repeat Step 2 as necessary. In the example, there are no more parentheses.
Evaluate the remaining expression, again following the usual order of operations. In the example 4*29 = 116. Note that without parentheses 4*3*8-5^2 +2 = 4*3*7-25+2 = 12*7-25+2 = 84-25+2 = 61, and you can see that parentheses make a big difference.