Write the subtraction expression. For example, you might have ^3√64 - ^4√16 (the cube root of 64 minus the fourth root of 16).
Simplify each separate radical expression. In this case, you must find out what number multiplied times itself three times equals 64. The answer for the cube root of 64 is 4. You also must figure out what number multiplied times itself equals 16. The answer, therefore, for the fourth root of 16 is 2. You can determine roots of your base by making guesses and then performing the multiplications to check your answers, or you can use online radical/root calculator tools (see Resources).
Rewrite the subtraction expression with the roots that you obtained in step 2. In this example, you would write 4 - 2.
Subtract the second value from the first to find your answer. In this case, you would subtract 2 from 4 to get 2.