Look at the word as a whole and allow the first thought to come to mind. Often simple cases of transposed letters appear as normal words at first glance. Even if there is a misspelling, your brain may process the word correctly right away.
Look at beginning and ending letters for clues. In jumbled word puzzles, the beginning and ending letters may be in their correct positions.
Look for possibilities of letter clusters in order to find clues to the word. Examples of common clusters include "sh," "ch," "pr," "tr," "st" and "cl."
Check for letters that commonly compose prefixes and suffixes. Examples include "in," "pre," "de," "ing" and "ion."
Try different letters at the beginning of a word. If you can get the first letter or two of the word, you are more likely to be able to unscramble the rest of the transposed letters.