- Advocating for and securing the passage of the 18th Amendment to the U.S. Constitution, which instituted nationwide prohibition of alcohol
- Establishing the Women's Christian Temperance Union (WCTU) Publishing House, which produced and disseminated educational materials about the dangers of alcohol and the benefits of temperance
- Organizing local and national campaigns to raise awareness about the harmful effects of alcohol and to encourage people to abstain from drinking
- Lobbying state legislatures to pass laws restricting the sale and consumption of alcohol
- Supporting women's suffrage, as many suffragists believed that women's right to vote was essential for achieving prohibition
- Establishing settlement houses and other social service programs to provide support for people struggling with alcohol addiction and other social problems
The CTU's efforts were instrumental in shaping public opinion and government policy on alcohol regulation, and its legacy continues to influence debates about substance use and public health.