Get credit for what you already know. The CLEP program (see related eHows) utilized by a lot of colleges and universities can give you a leg up on many degree programs.
Transfer all relevant academic credits you may have already earned (see related eHow). Credits earned from an accredited school, even 10 years earlier, can usually be applied to your new program.
Explore the flexible class schedules many colleges and universities now offer for working adults. In addition to evening and weekend classes, look into mini-semester and summer schedules.
Get your employer to pay the bill. If your studies are at all related to your job responsibilities, it's likely your company will reimburse at least part of your tuition.
Plan how you will manage your time to accommodate the additional work your classes will require. In addition to actual class time, allow at least 5 hours each week for homework, projects and study time.