* The students are in the classroom. (Simple and straightforward)
* The students are in their classroom. (Implies a specific classroom belonging to them)
* The students are sitting in the classroom. (Specifies their posture)
* The students are currently in the classroom. (Emphasizes the present time)
* The students are located in the classroom. (More formal)
* The class is in session/in the classroom. (Focuses on the class as a whole)
The best option depends on the context.