- epicenter: the point on the earth's surface directly above the hypocenter, the point at which an earthquake starts.
- epidemic: a widespread occurrence of a disease.
- epidermis: the outermost layer of the skin.
- epiglottis: a flap of cartilage that covers the opening to the larynx when we swallow.
- epilepsy: a neurological disorder that causes seizures.
- epiphany: a sudden realization or understanding of something.
- episcopal: relating to a bishop or bishops.
- episode: a distinct part of a story or event.
- epistemology: the study of the nature of knowledge.
- epistaxis: nosebleeds.