For example:
- The sky is clear, therefore we can go for a walk.
- She studied hard, therefore she got good grades.
- He did not study, therefore he failed the test.
However, if therefore is used as an adverb within a sentence, it does not require a comma.
For example:
- Therefore, we can conclude that the hypothesis is correct.
- The experiment failed; therefore, we need to start over.
- He arrived therefore late for the meeting.