Switched-On School House requires an English language version of Windows XP with Service Pack 3, Windows Vista or Windows 7. Older versions can run on Windows 2000 and earlier. Microsoft .NET Framework 3.5 is not required to run Windows XP, Windows Vista or Windows 7 but, Microsoft recommends it.
Switched-On School House's system requirements page does not specifically list Microsoft .NET Framework 3.5 in either the minimum requirements or optimal requirements. Their required versions of Windows and Internet Explorer recommend the installation of Microsoft .NET Framework 3.5.
A home network is required only if use of the client feature in the 2010 version of Switched-On School House is desired. (see reference 2)
Switched-On School House 2010 requires Microsoft Internet Explorer 7 or higher. Internet Explorer 7 is included in Windows Vista and Windows 7. Users of Windows XP with Service Pack 3 installed can upgrade to IE 7 through Microsoft's automatic update system.