* What subject? First semester of what? High school? College? A specific course like Calculus I, Introduction to Psychology, or Organic Chemistry? The questions will be vastly different.
* What kind of question? Are you asking about the overarching theme or learning objective of the semester? A specific exam question? A question about the workload? A question about the professor's teaching style?
To help me answer your question, please provide more context. Tell me what subject and what kind of question you're looking for.