Importance of Sequence Alignment

Sequence alignment is important because it allows scientists to analyze protein strands (such as DNA and RNA) and determine where there are overlaps. These overlaps can show commonalities in evolution and they also allow scientists to better prepare vaccines against viruses, which are made of protein strands. There are three main types of sequence alignments: pairwise sequence alignment, multiple sequence alignment and structural sequence alignment.
  1. Pairwise Sequence Alignment

    • Pairwise sequence alignment looks at where two protein strands overlap in elemental chains. This is accomplished by writing out the elements in the protein chain and then noting where there are similar elemental chains.

    Multiple Sequence Alignment

    • Multiple sequence alignment is similar to pairwise sequence alignment, but is done with more than two protein strands. A multiple sequence alignment is frequently written out in a tree shape to make overlaps between the strands clear, because there are fewer overlaps than in a pairwise sequence alignment

    Structural Sequence Alignment

    • Unlike pairwise and multiple sequence alignments, a structural sequence alignment analyzes the entire structure of a protein strand. Structural sequence alignment must be visualized three-dimensionally.

    Examples of Protein Strands

    • The most common protein strands analyzed in the three types of sequence alignments are DNA and RNA strands, which are important for understanding how organisms evolve. Viruses can also be analyzed (especially in structural sequence alignment), which can lead to more effective vaccine creation.

    Language Sequence Alignment

    • Sequence alignment can also be used to analyze non-biological sequences, such as in language. This is done in the same fashion as pairwise sequence alignment, with two words written on top of each other and commonalities noted. Language sequence alignment is particularly useful in trying to find the etymology of words.

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