Students in U.S. history classes have the opportunity to write about any number of topics relating to the course and development of the United States politically, socially and intellectually. For example, you could look at the surge in juvenile delinquency in the 1950s. You could frame your thesis around why juvenile delinquency was such a problem. Look at what was popular at that time, from movies and music to books and clothes, or consider whether the perception of delinquency has changed.
In a sociology class, your thesis question should revolve around some social phenomenon. You could frame a thesis question around marriage and divorce rates in the United State or abroad. Look at different factors that could affect these rates, including religion, political affiliation, education level and societal expectations, among other things. Question, for example, whether couples in which both partners have at least a college degree are more or less prone to divorce than couples in which neither partner has a college degree.
In a political science class, you can write on topics ranging from political methodologies to international relations. You could begin writing your paper by questioning how the political environment in Chicago developed into what it is. Look at, for example, the history of political corruption in the city; look for trends that might suggest why that type of environment may exist, and why it exists in that major city but not in others.
If you're taking a class on classics or ancient history, you can question most aspects of ancient life. Question, for example, the importance of heroism in ancient texts. Look at texts such as Homer's "Odyssey" and "Iliad." Study depictions of heroes on vases and in sculptures. Consider the importance of heroism in individual societies. For example, look at trends in literature and artifacts to see where heroism seems to be mostly highly revered and look at examples where and why individual heroes have been deified.