* The killing of Candy's dog: This incident, though seemingly unrelated, highlights the brutality and callousness of the ranch environment. Candy is forced to kill his loyal dog because it's "no good" anymore. This foreshadows the vulnerability of the weak and the potential for violence on the ranch.
* Curley's wife's loneliness: Throughout the novel, she is presented as desperate for attention and connection. She seeks out Lennie, George, and the other men, desperate for someone to talk to. This isolation and desperation foreshadow her vulnerability to tragedy.
* Lennie's strength and accidental violence: Lennie's immense strength and his tendency to accidentally hurt people or animals (like the puppy and the mouse) foreshadow the potential for a tragic incident. His inability to control his strength and the potential for unintended harm are constantly present.
* The warnings about Curley's wife: George repeatedly warns Lennie about staying away from Curley's wife, emphasizing the danger she represents. This foreshadows the tragic encounter that will ultimately lead to her death.
* Curley's jealousy and aggression: Curley's possessiveness and tendency toward violence create a dangerous atmosphere. His suspicion of Lennie and his violent nature foreshadow the potential for conflict.
* The atmosphere of the ranch: The overall atmosphere of the ranch is one of isolation, loneliness, and violence. This creates a bleak backdrop for the events that unfold.
These incidents, though not directly related to Curley's wife's death, create a sense of foreboding and foreshadow the tragic events that will come to pass. The novel is full of warnings and hints that tragedy is inevitable.