1. Elena Michaels (Laura Vandervoort): A female werewolf and the show's protagonist, who is torn between her human life and her werewolf nature.
2. Clay Danvers (Greyston Holt): A werewolf and Elena's love interest, who is also the werewolf pack's Alpha.
3. Jeremy Danvers (Steve Lund): Clay's brother, a werewolf and a doctor who tries to help Elena control her werewolf abilities.
4. Paige Winterbourne (Kristen Holden-Ried): An ancient werewolf and the leader of the Mutts, a group of rogue werewolves.
5. Malcolm Danvers (Greg Bryk): Clay and Jeremy's father, who is also a werewolf and the former Alpha of the pack.
6. Diane McAdams (Cle Bennett): A human who works for the university's security department and is aware of the existence of werewolves.