The best laid schemes o' mice an' men,
Gang aft agley,
An' lea'e us nought but grief an' pain,
For promis'd joy!
The line "The best laid schemes o' mice an' men" is used as the title of the novella because it reflects the theme of the story. The novella tells the story of two migrant ranch workers, George Milton and Lennie Small, who dream of owning their own farm. However, their plans are thwarted by Lennie's mental disability, which leads to a series of tragic events.
The title Of Mice and Men is a reminder that even the best-laid plans can go awry, and that even the most seemingly insignificant creatures can have a profound impact on our lives.