1. Tragedy (τραγωδία, *tragoidia*): This is the closest fit, as tragedy inherently focuses on the downfall of a noble character due to a fatal flaw or external circumstances. It emphasizes the suffering of the main character and their eventual downfall.
2. Pathos (πάθος, *pathos*): This refers to the emotional impact of a story, often emphasizing feelings of sadness, pity, and empathy for the character's suffering.
3. Tragicomedy (τραγικοκωμωδία, *tragikokomoidia*): While still emphasizing the main character's suffering, tragicomedy combines elements of both tragedy and comedy. It often presents a tragic situation with moments of humor or irony.
4. Catharsis (κάθαρσις, *katharsis*): This concept refers to the emotional release experienced by the audience in witnessing the protagonist's suffering, as it allows them to confront and process their own fears and anxieties.
5. Hubris (ὕβρις, *hubris*): This refers to excessive pride or arrogance, which can lead to a character's downfall and suffering. While not a play genre, it's a key concept in tragedy and often contributes to the character's misfortunes.
Ultimately, the most fitting word depends on the specific nature of the play and the type of suffering experienced by the main character.