* Clemson University (FBS): A prominent member of the ACC (Atlantic Coast Conference), known for its strong football program.
* University of South Carolina (FBS): Another ACC member, also with a strong football tradition.
* Coastal Carolina University (FBS): A Sun Belt Conference member.
* Charleston Southern University (FCS): A member of the Big South Conference.
* Presbyterian College (FCS): A member of the Pioneer Football League.
These are the most well-known. There may be other smaller Division I schools in South Carolina in different sports, but these are the major ones.