College life as a whole is too broad of a topic for you to write your Communication 101 speech on, so narrow down your options. Topics such as "Dorm Life" and "How to Handle a Drunken Roommate" will be understood by almost everyone in your class, as most of you are about the same age and have experienced the same types of situations on campus. Other topics such as "How to Meet People," "Campus Safety" and "Student Government and You" also might be popularly received.
Students need to pay attention to their lives outside of their campus community, too, remembering they still have friends and family back in their hometowns. What happens there could affect your everyday life, and it could make a good topic for your COM 101 speech, such as "Dealing with A Loved One's Loss While Away From Your Family." You also might consider writing "Long-Distance Relationships: Worth It?" or "How to Stay Friends with Your Best Friends from High School."
Students often are concerned about what and where they eat. Dorm food is often regarded as unhealthy and flavorless, if not just downright bad. However, many colleges and universities do have specialized menus, if not whole cafeterias, dedicated to healthy and vegetarian options. Your speech topic can be "Healthy Eating on Campus" or "How to Keep Off the Freshman 15, 20 or 30." On the other hand, some students opt to eat less or not at all, resulting in eating disorders, so you could focus your speech on "How to Keep a Healthy Diet on Campus" or "Eating Disorders Formed at College."
Read your local newspaper to find out what's going on in town, and pick up your college's student newspaper to learn about campus happenings. Any government plan or proposal for either the town your school's in or on your campus could have an effect on your everyday life. Topics such as "New Local Liquor Laws" or "How Will the New Dorm Affect Your Life?" are a choice sure to attract attention.