- American Library Association Newbery Medal (1989) for his novel "Goosebumps: Welcome to Dead House"
- American Library Association Notable Books for Children (1992, 1993, 1994, 1996) for his "Goosebumps" series
- International Reading Association Children's Choice Awards (1993, 1994, 1995, 1996, 1997, 1998) for his "Goosebumps" series
- Edgar Allan Poe Award (2002) for his novel "The Haunting Hour: Don't Think About It"
- Stoker Award (2003) for his novel "The Haunting Hour: The Thirst"
- Disney Legends Award (2010) for his contributions to the entertainment industry
- Bram Stoker Award for Lifetime Achievement (2015) for his contributions to horror literature
Stine has also been inducted into the Society of Children's Book Writers and Illustrators Hall of Fame (1999), the Georgia Writers Hall of Fame (2011), and the National Cartoonists Society Hall of Fame (2013).