Marvel Comics:
* The Amazing Spider-Man: Byrne is known for his iconic run on the series in the early 1980s, which included the "Kraven's Last Hunt" storyline and the introduction of the black suit.
* Fantastic Four: He also had a notable run on this series, introducing characters like the Thing's girlfriend, Alicia Masters.
* X-Men: He is known for co-creating the character of Kitty Pryde and for his work on the "Days of Future Past" storyline.
* Alpha Flight: Byrne created the superhero team Alpha Flight, and wrote and illustrated the early issues.
* The Incredible Hulk: He wrote a substantial run on the Hulk series in the late 1970s.
* Captain America: Byrne also had a notable run on Captain America in the late 1970s.
DC Comics:
* Superman: Byrne wrote and drew the popular "Man of Steel" miniseries, which re-imagined Superman's origins.
* Wonder Woman: He wrote a run on the series in the late 1980s.
* The Question: Byrne's run on this series introduced a new origin story for the character, Vic Sage.
* Batman: He wrote several Batman stories, including "The Killing Joke," which is considered one of the most important Batman stories ever written.
Other Comics:
* The Avengers: Byrne had a short run on The Avengers, but made a significant contribution to the series.
* Iron Man: He wrote and drew a story for the Iron Man series.
* The Defenders: Byrne wrote and drew a story for The Defenders series.
* The Legion of Super-Heroes: Byrne wrote and drew a story for the Legion of Super-Heroes series.
* The New Mutants: Byrne wrote and drew some early issues of The New Mutants.
Non-Comics Work:
* Writing for television: He has written episodes of several television shows, including The Incredible Hulk, The Twilight Zone, and Beauty and the Beast.
* Film work: Byrne has worked as a screenwriter on several films, including the 1990 Superman movie Superman IV: The Quest for Peace.
* Other: Byrne is also an artist, illustrator, and writer of other works, including children's books and novels.
John F. Byrne has made significant contributions to comics, creating iconic stories and characters that continue to be influential today. He is also a prolific writer and artist who has worked on a wide range of other projects.