* Edmund, Earl of Rutland (17 May 1443 – 30 December 1460)
* George Plantagenet, 1st Duke of Clarence (21 October 1449 – 18 February 1478)
* Margaret of York (3 May 1446 – 30 November 1503) who married Charles the Bold
* William of York died young
* Mary of York
* Thomas Plantagenet, Earl of Warwick
Edward also had an unnamed sister that never received proper documentation. She became a nun shortly after birth on March 10, 1472