Here are some of his notable contributions:
* Developed the first gene targeting method in mice: This breakthrough allowed scientists to precisely modify genes in mice, creating animal models for studying human diseases.
* Pioneered the use of embryonic stem cells in gene targeting: This made the process more efficient and versatile.
* Established a major research program in gene targeting: Smithies' work has led to a wide range of applications in biomedical research, including the development of new drugs and therapies.
While he hasn't written novels or other literary works, his scientific contributions are significant and have been documented in numerous scientific publications.
If you're interested in learning more about his work, you can search for "Michael Smithies" on websites like PubMed or Google Scholar.