* Ramona Quimby: The protagonist of the series. She is a curious, adventurous, and imaginative young girl who often finds herself in trouble.
* Beezus Quimby: Ramona's older sister. She is more responsible and level-headed than Ramona, but she is also very caring.
* Roberta "Picky-Picky" Quimby: The youngest member of the Quimby family. She is a sweet and innocent child who idolizes Ramona.
* Mr. Quimby: Ramona's father. He works at the advertising agency.
* Mrs. Quimby: Ramona's mother. She stays at home to take care of the children.
Supporting Characters
* Henry Huggins: Ramona's friend and neighbor. He is a kind and resourceful boy.
* Daisy Webber: Ramona's best friend. She is a quiet and shy girl who loves to read.
* Willa Jean: Another one of Ramona's friends. She is a tomboy who loves to play sports.
* Mrs. Swenson: Ramona's neighbor and friend. She is a kind and elderly woman who is always happy to help Ramona out.
* Miss Binns: Ramona's teacher. She is a strict but fair woman.
* Howie Kemp: Henry Huggins' best friend. He is a small, shy boy who is picked on by the other boys in the neighborhood.
* Violet Henry: A friend of Ramona's. She is a smart and talented girl who is a bit full of herself.
* Scott Spencer: A friend of Henry's. He is a kind and caring boy who is always willing to help others.
* Mrs. Smedley: The owner of the local restaurant. She is a kind and generous woman who is always happy to give the kids free food.
Pets
* Ribsy: the family dog. He is a mischievous white sheepdog.
* Pickle: the family cat. He is a fluffy orange tabby.