General:
* The blight of poverty has ravaged the city's once-vibrant neighborhoods.
* The blight of the disease spread rapidly through the village.
* The blight of war has left the country in ruins.
More Specific:
* The blight on the potato crops caused a devastating famine.
* The blight on the roses meant the garden was filled with wilted blooms.
* The neighborhood was plagued by a blight of empty storefronts.
Figurative:
* His constant negativity was a blight on the team's morale.
* The blight of jealousy poisoned their friendship.
Remember that "blight" can be a noun, adjective, or verb, so the context determines its meaning.