- Syed Ahmad Khan: A prominent Muslim reformer, educator, and politician who founded AMU in 1875. He was also a leader of the Aligarh Movement, which sought to promote modern education among Indian Muslims.
- Muhammad Ali Jinnah: The founder of Pakistan and one of the leading figures in the Indian independence movement. He studied law at AMU and was involved in student politics during his time there.
- Maulana Abul Kalam Azad: A prominent Indian nationalist, Islamic scholar, and politician who served as the first education minister of independent India. He studied at AMU and was associated with the Khilafat Movement, which opposed British rule in India.
- Zakir Hussain: The third president of India and a renowned educationist. He studied at AMU and later became a faculty member there. He also served as the vice-chancellor of AMU from 1956 to 1962.
- Khan Abdul Ghaffar Khan: An Indian independence activist and political leader known as the "Frontier Gandhi." He studied at AMU and was involved in the Indian National Congress during his time there.