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1. University of Pennsylvania
- Founded: 1765
- Location: Philadelphia, Pennsylvania
- Notable Alumni: Benjamin Rush, William Pepper, Josiah Bartlett
2. Columbia University College of Physicians and Surgeons
- Founded: 1767
- Location: New York City, New York
- Notable Alumni: Valentine Mott, John Peters, Allan Mclean
3. Harvard Medical School
- Founded: 1782
- Location: Boston, Massachusetts
- Notable Alumni: Oliver Wendell Holmes Sr., William Osler, George Minot
4. Yale School of Medicine
- Founded: 1810
- Location: New Haven, Connecticut
- Notable Alumni: Nathan Smith, Benjamin Silliman, John P.C. Griffith
5. Dartmouth Medical School
- Founded: 1820
- Location: Hanover, New Hampshire
- Notable Alumni: Daniel Webster, Nathan Smith, Moses Giddings
6. Charleston Medical University
- Founded: 1823
- Location: Charleston, South Carolina
- Notable Alumni: John C. Calhoun, Joseph Ignace Guillotin, James Marion Sims
7. University of Maryland School of Medicine
- Founded: 1827
- Location: Baltimore, Maryland
- Notable Alumni: John Shaw Billings, William Welch, William Halsted
8. Louisiana State University Health Sciences Center New Orleans
- Founded: 1834
- Location: New Orleans, Louisiana
- Notable Alumni: Rudolf Matas, Alton Ochsner, C. Everett Koop
9. Albany Medical College
- Founded: 1838
- Location: Albany, New York
- Notable Alumni: Erastus Corning, Elizabet Blackwell, Samuel Willard
10. University of Illinois at Chicago College of Medicine
- Founded: 1859
- Location: Chicago, Illinois
- Notable Alumni: Albert H. Montgomery, Joseph B. DeLee, Hugh T. Patrick
These medical schools have a rich history and have played significant roles in education, research, and healthcare in the United States.