* Death of his mother-in-law, Maria Clemm: In January 1846, Poe's mother-in-law, Maria Clemm, who was a constant source of love and support, passed away after a long illness. This was a devastating loss for Poe, who was deeply devoted to her.
* Death of his young wife, Virginia: Later in 1846, on January 30th, Poe's beloved wife, Virginia, succumbed to tuberculosis. She was only 24 years old. This was a profound loss for Poe, who had a deep and passionate love for her. He was completely heartbroken and devastated. This tragedy likely contributed to his own decline in health and mental state.
The year 1846 is considered a turning point in Poe's life, marking the beginning of a downward spiral that eventually led to his own tragic death in 1849. These personal losses, coupled with ongoing financial struggles, likely played a significant role in his psychological and physical deterioration.