* 1996: Favorite Rap/Hip-Hop Album (All Eyez on Me)
* 1997: Favorite Rap/Hip-Hop Artist
* 1997: Favorite Rap/Hip-Hop Album (The Don Killuminati: The 7 Day Theory)
BET Awards
* 1996: Best Male Hip-Hop Artist
* 1997: Best Male Hip-Hop Artist
Billboard Music Awards
* 1996: Top R&B/Hip-Hop Artist
* 1996: Top R&B/Hip-Hop Album (All Eyez on Me)
* 1997: Top R&B/Hip-Hop Artist
* 1997: Top R&B/Hip-Hop Album (The Don Killuminati: The 7 Day Theory)
BRIT Awards
* 1997: International Male Solo Artist
Grammy Awards
* 1996: Best Rap Album (All Eyez on Me)
* 1997: Best Rap Album (The Don Killuminati: The 7 Day Theory)
MTV Video Music Awards
* 1995: Best Rap Video ("California Love")
* 1995: Best Video from a Film ("Dear Mama")
* 1996: Best Rap Video ("California Love (Remix)")
* 1997: Best Rap Video ("I Ain't Mad at Cha")
Soul Train Music Awards
* 1996: Best Rap Album (All Eyez on Me)
* 1997: Best Rap Album (The Don Killuminati: The 7 Day Theory)
Other awards
* 1996: Source Award for Lyricist of the Year
* 1996: Vibe Award for Best Rapper
* 1997: The Source Award for Album of the Year (The Don Killuminati: The 7 Day Theory)
* 1997: The Source Award for Male Artist of the Year
* 1997: The Source Award for Lyricist of the Year