* NFL Comeback Player of the Year (2011)
* NFL Quarterback of the Year (2011)
* NFL Passing Yards Leader (2011, 2012)
* NFL Playoff Passing Yards Leader (2021)
* Pro Bowl (2014, 2016, 2017, 2018)
* First-team All-Pro (2014)
* Second-team All-Pro (2011)
* NFL All-Rookie Team (2009)
* Heisman Trophy (2006)
* Maxwell Award (2006)
* Davey O'Brien Award (2006)
* Walter Camp Award (2006)
* Johnny Unitas Golden Arm Award (2006)
* Archie Griffin Award (2006)