* Vivian Baptiste: Jefferson's Godmother, a strong and outspoken woman who fiercely advocates for Jefferson's humanity and dignity. She embodies resilience and hope in the face of racism and injustice.
* Grant Wiggins: Jefferson's teacher and a man struggling with his own identity and purpose in the segregated South. While not a woman, Grant plays a vital role in the story, particularly in his relationship with Vivian and his efforts to help Jefferson find meaning in his final days.
While there are other female characters in the novel, these two are the most prominent and central to the narrative.