* Theories of Mass Communication (1966) - This book, co-authored with his wife, Lois DeFleur, provided a comprehensive overview of theories explaining the effects of mass media on individuals and society. It became a standard text in communication studies.
* Mass Communication: Concepts and Issues (1970) - This book aimed to explain the social processes underlying the production, distribution, and consumption of mass media. It also delved into the impact of mass media on individuals and society.
* Sociology of Mass Communication (1978) - This book, co-authored with Everette E. Dennis, presented a sociological perspective on mass communication, examining the role of media in shaping social values, beliefs, and behaviors.
* Mass Communication and Society (1985) - This book, co-authored with Lois DeFleur, offered a broad overview of mass communication, covering topics like media institutions, communication processes, and the impact of media on social life.
DeFleur also contributed to the development of communication theory, co-authoring works like Mass Communication Theory: A Source Book (1975) and The Third Person Effect (1985) with Sandra Ball-Rokeach. He was a prolific writer and his works significantly shaped the understanding of mass communication and its social implications.