While there's no definitive proof, strong evidence points to this conclusion:
* The poem's themes: The poem's central themes of love, loss, and the enduring power of memory resonate deeply with Poe's own grief over Virginia's death.
* The poem's imagery: The poem's descriptions of the young, beautiful Annabel Lee and the idyllic setting where she lived align with Poe's idealized image of his wife.
* The poem's publication: Poe wrote "Annabel Lee" in 1849, just two years after Virginia's death, and published it in 1849, suggesting its connection to his recent loss.
However, it's crucial to acknowledge that Poe never explicitly confirmed that "Annabel Lee" was directly about Virginia. As with many of Poe's works, the poem's meaning remains open to interpretation and debate.