* "The Simpsons #1" (1993): The first issue of the main Simpsons comic series is often considered the rarest and most sought-after. It's worth noting that this first issue actually had two covers, a regular and a variant, making the variant cover even more rare.
* "The Simpsons #300" (2015): This issue was a milestone for the series and featured a special "Simpsons 30th Anniversary" cover. While it may have had a higher print run than #1, it's a significant issue for collectors.
* "The Simpsons #79: The Adventures of Bartman" (2000): This issue featured a special "Bartman" story and cover, and it's considered quite rare, particularly in good condition.
* "The Simpsons Comics #1" (1989): This is actually a pre-cursor to the main series and features a unique cover. It's not as well-known as the later issues, making it a rare find.
It's important to note that the value and rarity of these comics can fluctuate significantly depending on the condition of the comic, the variant cover, and the collector's market. If you're looking to buy or sell a rare Simpsons comic, it's best to consult with a reputable comic book dealer or auction house for an accurate appraisal.