You're likely thinking of
"Get Fuzzy" by Jim Davis. It features a cynical, grumpy old woman named
"Satchel", who lives with a lazy, sarcastic cat named
"Rob" and a sweet, lovable dog named
"Buford".
While the main focus of the strip is on the comedic relationship between the animals, Satchel often provides witty and cynical commentary on the world around her.