There are a few possibilities for what you might be thinking of:
* "Destroy All Humans" video game series - Developed by Pandemic Studios and published by THQ. The game is a satirical sci-fi action-adventure title about a Cryptosporidium alien.
* "Vampirella" comic book series - Created by Forrest J. Ackerman and published by Warren Publishing, featuring a vampire hunter named Vampirella. While she doesn't "destroy all vampires," she does hunt them.
* "Buffy the Vampire Slayer" comic book series - A continuation of the popular TV show, featuring the titular vampire slayer, Buffy Summers, fighting vampires and other supernatural creatures.
If you can provide more context about the comic you're looking for, I can help you find the correct answer!