Yuki Cross: A kind and compassionate girl who was adopted by Kaname Kuran and Kaien Cross after her parents were killed by a vampire. Yuki is unaware of her true vampire heritage and has dedicated her life to protecting humans from vampires.
Zero Kiryu: A vampire hunter who seeks revenge against all vampires for the death of his family. Zero has a complicated relationship with Yuki and struggles to control his bloodlust.
Kaname Kuran: The Pureblood vampire and president of the Night Class. Kaname is a powerful and mysterious vampire who has a deep bond with Yuki.
Yuuki Kuran: Yuki's twin brother and a Pureblood vampire. Yuuki is the only other Pureblood besides Kaname and has been sealed away for much of Yuki's life.
Rido Kuran: Kaname and Yuuki's father and the main antagonist of the series. Rido is a ruthless and evil vampire who seeks to destroy Kaname and his allies.
Maria Kurenai: A former vampire hunter and Zero's childhood friend. Maria is loyal to Zero and often helps him in his missions.
Ruka Souen: A Level E vampire and a member of the Night Class. Ruka is known for his sadistic and violent tendencies.
Aido Hanabusa: A Level B vampire and a member of the Night Class. Aido is often flirtatious and arrogant but also deeply loyal to Kaname.
Seiren: A Level A vampire and a member of the Night Class. Seiren is a quiet and intelligent vampire who serves as an observer within the Night Class.
Ichiru Kiryu: Zero's twin brother and a vampire. Ichiru has a complicated relationship with his brother and frequently clashes with him due to their contrasting views on vampires and humans.