Chapter 1 is set on a large plantation in Virginia, called "The Hermitage". The plantation is owned by a wealthy plantation owner named "Mr. Reynolds", and it is home to over a hundred slaves.
The protagonist of the book, an enslaved woman named "Rose", lives and works on "The Hermitage". She is constantly mistreated by her owners and is determined to escape.
Chapter 15 is set in a small Quaker community in Pennsylvania, called "Byberry". The Quaker community is a safe haven for escaped slaves, and it is where Rose eventually finds freedom.
The change in setting is significant because it highlights the journey that Rose takes to escape slavery and find freedom. It shows the many obstacles that she faces along the way, and it also shows the support and kindness that she receives from others.