Where do you put commas in the sentence most famous novel The Scarlet Letter has been read by countless schoolchildren?

The correct placement of commas in the sentence is:

"Most famously, the novel *The Scarlet Letter* has been read by countless schoolchildren."

Here's why:

* "Most famously" is an introductory phrase, so it needs a comma after it.

* "*The Scarlet Letter*" is the title of a book, so it needs to be italicized.

* There are no other commas needed in the sentence.