Perhaps you're thinking of:
* "Ulysses" by James Joyce: This is a famous modernist novel, and its manuscript is housed in the James Joyce Collection at the University of Buffalo, New York.
* Another work by James Joyce: Perhaps you're thinking of a different work by James Joyce. If you can provide more information about the title or any details about the manuscript, I might be able to help you find it.
* A different author named James: It's also possible you are thinking of a different author named James who wrote a work called "Ulysses". If you have any other details about this work, such as publication date or genre, it would be helpful.
Please provide more context so I can assist you in finding the original manuscript.