Opal's life is transformed when she finds a scruffy, orange-and-white dog at the Winn-Dixie supermarket. She names him after the store and takes him home, much to her father's initial disapproval. Winn-Dixie becomes Opal's best friend, helping her overcome her shyness and loneliness.
Through Winn-Dixie, Opal forms connections with the quirky and colorful people of Naomi. She befriends Miss Franny, the librarian who shares stories and wisdom; the preacher's wife, Gloria, who helps Opal understand the power of forgiveness; and Otis, the kind-hearted store owner who teaches her about loyalty.
Opal and Winn-Dixie's adventures in Naomi are full of laughter, tears, and lessons about friendship, family, and the power of love. Winn-Dixie helps Opal find her voice, her confidence, and a sense of belonging in the world. The novel ultimately celebrates the magic of friendship, the importance of community, and the unconditional love that a dog can bring.