* George's desire for revenge against his horrible grandma: George's grandma is a truly awful person who constantly belittles and mistreats him. This fuels his desire to create a medicine that will turn her into a giant, allowing him to finally get his revenge.
* The consequences of George's actions: While driven by his anger, George's creation of the medicine has serious consequences, not only for his grandma, but for everyone around him. The medicine is wildly unpredictable, and its effects create a hilarious and chaotic situation.
* George's struggle with guilt and responsibility: After the initial excitement of seeing his plan come to fruition, George realizes the severity of his actions and feels a deep sense of guilt. He must confront the ethical implications of his revenge and learn to take responsibility for his actions.
While the conflict is primarily driven by George's desire for revenge, the story also explores themes of family relationships, the consequences of one's actions, and the power of imagination.