* Johnsy: A young woman who is seriously ill with pneumonia and believes that she will die when the last leaf falls from an ivy vine outside her window.
Other Characters
* Sue: Johnsy's best friend and roommate, a struggling artist.
* Berman: An elderly artist who lives in the same building as Johnsy and Sue.
* Mr. Pneumonia: The personification of pneumonia, a deadly disease.
* The Last Leaf: The final leaf on the ivy vine, which becomes a symbol of hope for Johnsy.