* Holden's lack of close relationships. Holden doesn't have any close friends or family members that he can really connect with. He's always felt like an outsider, and he doesn't trust people easily. This lack of close relationships makes him feel even more lonely and alone.
* Holden's search for meaning in life. Holden is struggling to find meaning in his life. He doesn't know what he wants to do or what he wants to be. This lack of direction leads to feelings of emptiness and loneliness.
* Holden's mental illness. Holden is suffering from mental illness, which contributes to his loneliness. He is depressed and anxious, and he has difficulty coping with his emotions. This makes it difficult for him to connect with others and feel close to anyone.